POS0704 RISK FACTORS OF DEPRESSION AND ANXIETY IN PATIENTS WITH TAKAYASU ARTERITIS

Background Takayasu arteritis (TA) is associated with an increased risk of developing complicated comorbidities, which can bring both psychological and physical burdens to the patients. Most cases are young female patients onset age 10 40 years [1]. Psychological disorders have long been recognized as important comorbidities immune diseases. In case rheumatoid progress, comorbid depression anxiety would increase mortality heighten medication, prognostic economic burden. TA, there haven’t identified whether may lead inaccurate evaluation disease status lower quality life [2-5]. The emotional state generated by TA should not be ignored. primary aim this study was investigate factors in TA. Objectives research arteritis. Methods observational, longitudianl cohort study, 86 TAK were respectively divided into two groups or without identify factors. Zung Self-Rating Depression Anxiety Scale (SDS/SAS) widely applied many medical researches related mental health, displays convincing results a remarkable degree consensus on diagnosis mood disorders. Results Individual patient data available from subjects, whom 23 had depression, 15 anxiety. independently Carotidynia, elevated IL-6, decreased Hb (OR [95%CI] 7.116 [11.508–33.586], p=0.0010; OR 6.669 [1.746–25.470], p=0.005; 3.882[1.214–12.420], p=0.020) respectively. We used correlation analysis find out association between level IL-6 SDS, SAS scores (r=0.337, p=0.002; r=0.280, p=0.010). levels Completement 3, NIH, ITAS.A ITAS2010 similarly correlated SDS score (r=0.232, p=0.032; p=0.009; r=0.332, r=0.323, p=0.002), wasn’t seemed score. Conclusion Clinicians alert for predisposing given more positive treatment essentially control improve their life. References [1]Vanoli M, Bacchiani G, Origg L, Scorza R. Takayasu’s arteritis: changing disease. Journal nephrology. 2001;14(6):497-505. [2]Nerurkar Siebert S, McInnes IB, Cavanagh J. Rheumatoid arthritis depression: inflammatory perspective. Lancet Psychiatry. 2019;6(2):164-73. [3]Matcham F, Rayner Steer Hotopf M. prevalence arthritis: systematic review meta-analysis. Rheumatology. 2013;52(12):2136-48. [4]Zhang Fu T, Yin R, Zhang Q, Shen B. Prevalence systemic lupus erythematosus: BMC psychiatry. 2017;17(1):1-14. [5]Moustafa AT, Moazzami Engel Bangert E, Hassanein Marzouk et al., editors. metric Seminars rheumatism; 2020: Elsevier. Figure 1. Acknowledgements: NIL. Disclosure Interests None Declared.